Quality of Survival and Growth in Children and Young Adults in the PNET4 European Controlled Trial of Hyperfractionated Versus Conventional Radiation Therapy for Standard-Risk Medulloblastoma

Kennedy C, Bull K, Chevignard M, Culliford D, Dörr HG, Doz F, Kortmann RD, Lannering B, Massimino M, Navajas Gutierrez A, Rutkowski S, Spoudeas HA, Calaminus G (2014)

Publication Type: Journal article

Publication year: 2014

Journal

International Journal of Radiation Oncology Biology Physics Elsevier

Publisher: Elsevier

Book Volume: 88

Pages Range: 292-300

Journal Issue: 2

DOI: 10.1016/j.ijrobp.2013.09.046

Abstract

To compare quality of survival in "standard-risk" medulloblastoma after hyperfractionated radiation therapy of the central nervous system with that after standard radiation therapy, combined with a chemotherapy regimen common to both treatment arms, in the PNET4 randomised controlled trial.Participants in the PNET4 trial and their parents/caregivers in 7 participating anonymized countries completed standardized questionnaires in their own language on executive function, health status, behavior, health-related quality of life, and medical, educational, employment, and social information. Pre- and postoperative neurologic status and serial heights and weights were also recorded.Data were provided by 151 of 244 eligible survivors (62%) at a median age at assessment of 15.2 years and median interval from diagnosis of 5.8 years. Compared with standard radiation therapy, hyperfractionated radiation therapy was associated with lower (ie, better) z-scores for executive function in all participants (mean intergroup difference 0.48 SDs, 95% confidence interval 0.16-0.81, P=.004), but health status, behavioral difficulties, and health-related quality of life z-scores were similar in the 2 treatment arms. Data on hearing impairment were equivocal. Hyperfractionated radiation therapy was also associated with greater decrement in height z-scores (mean intergroup difference 0.43 SDs, 95% confidence interval 0.10-0.76, P=.011).Hyperfractionated radiation therapy was associated with better executive function and worse growth but without accompanying change in health status, behavior, or quality of life.

Authors with CRIS profile

Helmuth-Günther Dörr Professur für Kinderheilkunde mit dem Schwerpunkt Kinder-Endokrinologie und Diabetologie (Stiftungsprofessur)

Involved external institutions

University of Southampton GB United Kingdom (GB) Hôpitaux de Saint-Maurice FR France (FR) Institut Curie FR France (FR) Universität Leipzig DE Germany (DE) University of Gothenburg / Göteborgs universitet SE Sweden (SE) Istituto di ricovero e cura a carattere scientifico (IRCCS) IT Italy (IT) Hospital Universitario de Cruces ES Spain (ES) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) University College London (UCL) GB United Kingdom (GB) Westfälische Wilhelms-Universität (WWU) Münster DE Germany (DE)

How to cite

APA:

Kennedy, C., Bull, K., Chevignard, M., Culliford, D., Dörr, H.-G., Doz, F.,... Calaminus, G. (2014). Quality of Survival and Growth in Children and Young Adults in the PNET4 European Controlled Trial of Hyperfractionated Versus Conventional Radiation Therapy for Standard-Risk Medulloblastoma. International Journal of Radiation Oncology Biology Physics, 88(2), 292-300. https://doi.org/10.1016/j.ijrobp.2013.09.046

MLA:

Kennedy, Colin, et al. "Quality of Survival and Growth in Children and Young Adults in the PNET4 European Controlled Trial of Hyperfractionated Versus Conventional Radiation Therapy for Standard-Risk Medulloblastoma." International Journal of Radiation Oncology Biology Physics 88.2 (2014): 292-300.

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