Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease
Morgen K, Ramirez A, Frölich L, Tost H, Plichta MM, Kölsch H, Rakebrandt F, Rienhoff O, Jessen F, Peters O, Jahn H, Luckhaus C, Hüll M, Gertz HJ, Schröder J, Hampel H, Teipel SJ, Pantel J, Heuser I, Wiltfang J, Rüther E, Kornhuber J, Maier W, Meyer-Lindenberg A (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: Elsevier Masson
Book Volume: 10
Pages Range: S269-76
Journal Issue: 5 Suppl
DOI: 10.1016/j.jalz.2013.11.001
Abstract
Evidence has emerged indicating that the ?4 allele of APOE and PICALM interact in conferring risk of Alzheimer's disease (AD). The biologic basis of this interaction is unclear, but it is likely to have phenotypic relevance and contribute to the structural and clinical heterogeneity of AD.The aim of this study was to investigate interaction effects of the APOE ?4 allele and the alleles at the single-nucleotide polymorphism rs3851179 located in the PICALM locus. We analyzed brain volumes and cognitive phenotypes of 165 patients with early AD dementia.There was a synergistic adverse effect of homozygosity for the PICALM risk allele G in rs3851179 and APOE ?4 on volume in prefrontal and performance on the Trail Making Test A, which is sensitive to processing speed and working memory function.The data suggest a neural mechanism for APOE-PICALM interactions in patients with manifest AD and indicate that the PICALM genotype modulates both brain atrophy and cognitive performance in APOE ?4 carriers.
Authors with CRIS profile
Involved external institutions
Albert-Ludwigs-Universität Freiburg
Germany (DE)
Universität Leipzig
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
University of Paris 6 - Pierre et Marie Curie / Université Paris VI Pierre et Marie Curie (UPMC)
France (FR)
Universität Rostock
Germany (DE)
Goethe-Universität Frankfurt am Main
Germany (DE)
Rheinische Friedrich-Wilhelms-Universität Bonn
Germany (DE)
Georg-August-Universität Göttingen
Germany (DE)
Universität Duisburg-Essen (UDE)
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Universität Hamburg (UHH)
Germany (DE)
Heinrich-Heine-Universität Düsseldorf
Germany (DE)
Germany (DE)
Universität Leipzig
Germany (DE)
Ruprecht-Karls-Universität Heidelberg
Germany (DE)
University of Paris 6 - Pierre et Marie Curie / Université Paris VI Pierre et Marie Curie (UPMC)
France (FR)
Universität Rostock
Germany (DE)
Goethe-Universität Frankfurt am Main
Germany (DE)
Rheinische Friedrich-Wilhelms-Universität Bonn
Germany (DE)
Georg-August-Universität Göttingen
Germany (DE)
Universität Duisburg-Essen (UDE)
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Universität Hamburg (UHH)
Germany (DE)
Heinrich-Heine-Universität Düsseldorf
Germany (DE)
How to cite
APA:
Morgen, K., Ramirez, A., Frölich, L., Tost, H., Plichta, M.M., Kölsch, H.,... Meyer-Lindenberg, A. (2014). Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease. Alzheimers & Dementia, 10(5 Suppl), S269-76. https://doi.org/10.1016/j.jalz.2013.11.001
MLA:
Morgen, Katrin, et al. "Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease." Alzheimers & Dementia 10.5 Suppl (2014): S269-76.
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