Lomlim L, Einsiedel J, Heinemann FW, Meyer K, Gmeiner P (2008)
Publication Type: Journal article, Original article
Publication year: 2008
Original Authors: Lomlim L., Einsiedel J., Heinemann F.W., Meyer K., Gmeiner P.
Publisher: American Chemical Society
Book Volume: 73
Pages Range: 3608-3611
Journal Issue: 9
DOI: 10.1021/jo702573z
(Chemical Equation Presented) A practical and efficient synthesis of spirobarbiturates of type III is reported when NH acidity of the imide function of the hydrophilic linker element allowed the introduction of different substituents. Structural characterization, which was based on both X-ray crystallography and spectroscopic investigations, indicated type II β-turn formation. Introduction of the molecular scaffold into solid phase peptide synthesis gave rise to spirocyclic neuropeptide analogs. © 2008 American Chemical Society.
APA:
Lomlim, L., Einsiedel, J., Heinemann, F.W., Meyer, K., & Gmeiner, P. (2008). Proline derived spirobarbiturates as highly effective β-turn mimetics incorporating polar and functionalizable constraint elements. Journal of Organic Chemistry, 73(9), 3608-3611. https://doi.org/10.1021/jo702573z
MLA:
Lomlim, Luelak, et al. "Proline derived spirobarbiturates as highly effective β-turn mimetics incorporating polar and functionalizable constraint elements." Journal of Organic Chemistry 73.9 (2008): 3608-3611.
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