Koch S, Finotto S (2015)
Publication Type: Journal article
Publication year: 2015
Publisher: Karger
Book Volume: 7
Pages Range: 224-30
Journal Issue: 3
DOI: 10.1159/000369459
Type III interferons (IFNs), or IFN-?, are known to have potent antiviral and antiproliferative activities. It inhibits viral replication and upregulates cytotoxic responses to virally infected cells. Besides these characteristics, IFN-? also has additional activities in the immune system. In fact, it induces the proliferation of Foxp3-expressing regulatory T cells mediated in part by dendritic cells and inhibit the production of IL-5 and IL-13 in vitro. Regulatory T cells and the Th2 cytokines like IL-5 and IL-13 play important roles in the pathogenesis of allergic asthma. In humans, there seems to be an inverse link between IFN-? and the severity of allergic asthma and allergic asthma exacerbations. Asthmatic patients, without a detectable viral infection show an inverse correlation between IL-28 and IL-29 mRNA levels and severity of allergic responses in the airways. These additional features of IFN-? that affect the adaptive immune system make it a potential immunotherapeutic agent for the treatment of allergic asthma.
APA:
Koch, S., & Finotto, S. (2015). Role of Interferon-? in Allergic Asthma. Journal of Innate Immunity, 7(3), 224-30. https://doi.org/10.1159/000369459
MLA:
Koch, Sonja, and Susetta Finotto. "Role of Interferon-? in Allergic Asthma." Journal of Innate Immunity 7.3 (2015): 224-30.
BibTeX: Download