Basophils in inflammation

Schwartz C, Eberle J, Vöhringer D (2015)

Publication Type: Journal article

Publication year: 2015

Journal

European Journal of Pharmacology Elsevier

Publisher: Elsevier

DOI: 10.1016/j.ejphar.2015.04.049

Abstract

Basophils are functionally closely related to mast cells. Both cell types express the high-affinity IgE receptor (Fc?RI) and rapidly release preformed mediator from intracellular stores upon IgE-mediated activation. However, in contrast to mast cells basophils finish their maturation in the bone marrow and have a lifespan of only 2-3 days. Basophil numbers increase in response to IL-3 or TSLP and migrate into tissues to promote type 2 immune responses. Here we review recent advances regarding the pro- and anti-inflammatory functions of basophils in murine models and human allergic inflammation of the skin, lung and intestine.

Authors with CRIS profile

Christian Schwartz Department of Infection Biology Jörg Eberle Professur für Infektionsabwehr und Toleranz David Vöhringer Professur für Infektionsabwehr und Toleranz

How to cite

APA:

Schwartz, C., Eberle, J., & Vöhringer, D. (2015). Basophils in inflammation. European Journal of Pharmacology. https://doi.org/10.1016/j.ejphar.2015.04.049

MLA:

Schwartz, Christian, Jörg Eberle, and David Vöhringer. "Basophils in inflammation." European Journal of Pharmacology (2015).

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