Wegner M (2009)
Publication Type: Journal article, Original article
Publication year: 2009
Publisher: American Society for Biochemistry and Molecular Biology
Pages Range: 1269-1280
Journal Issue: 50
DOI: 10.1194/jlr.M800531-JLR200
Although the transcription factor Sox8 is broadly expressed during embryogenesis in developing ectodermal and mesodermal tissues, mice develop surprisingly normally in the absence of Sox8. Phenotypes in adult Sox8-deficient mice include mild osteopenia, late-onset male infertility, and reduced weight. We show here that progressive degeneration of adipose tissue in adult Sox8-deficient mice significantly contributes to weight reduction. Although serum levels of leptin, IGF-1, and noradrenaline were altered in Sox8-deficient mice, these changes could not explain the observed phenotype. Other serum parameters, including indicators of glucose metabolism, were largely normal. However, expression of the preadipocyte marker Pref-1 was elevated in adipose tissues of Sox8-deficient mice. This increase correlated with an impaired differentiation of Sox8-deficient fibroblasts to adipocytes in culture, a defect that could be rescued by reintroducing Sox8 into the cells. Furthermore, Sox8 levels were higher in mesodermal precursors than in mature adipocytes. We postulate a precursor-intrinsic role of Sox8 during replenishment of the adipocyte pool in adult mice and assume that disturbance of this function significantly contributes to adipose tissue degeneration in Sox8-deficient mice. Copyright © 2009 by the American Society for Biochemistry and Molecular Biology, Inc.
APA:
Wegner, M. (2009). Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor. Journal of Lipid Research, 50, 1269-1280. https://doi.org/10.1194/jlr.M800531-JLR200
MLA:
Wegner, Michael. "Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor." Journal of Lipid Research 50 (2009): 1269-1280.
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