Karyotype complexity and prognosis in acute myeloid leukemia

Stoelzel F, Mohr B, Kramer M, Oelschlaegel U, Bochtler T, Berdel WE, Kaufmann M, Baldus CD, Schaefer-Eckart K, Stuhlmann R, Einsele H, Krause S, Serve H, Haenel M, Herbst R, Neubauer A, Sohlbach K, Mayer J, Middeke JM, Platzbecker U, Schaich M, Kraemer A, Roellig C, Schetelig J, Bornhaeuser M, Ehninger G (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Blood Cancer Journal Nature Publishing Group / Nature Publishing Group: Open Access Journals - Option B

Book Volume: 6

Pages Range: e386

DOI: 10.1038/bcj.2015.114

Abstract

A complex aberrant karyotype consisting of multiple unrelated cytogenetic abnormalities is associated with poor prognosis in patients with acute myeloid leukemia (AML). The European Leukemia Net classification and the UK Medical Research Council recommendation provide prognostic categories that differ in the definition of unbalanced aberrations as well as the number of single aberrations. The aim of this study on 3526 AML patients was to redefine and validate a cutoff for karyotype complexity in AML with regard to adverse prognosis. Our study demonstrated that (1) patients with a pure hyperdiploid karyotype have an adverse risk irrespective of the number of chromosomal gains, (2) patients with translocation t(9;11)(p21~22;q23) have an intermediate risk independent of the number of additional aberrations, (3) patients with ?4 abnormalities have an adverse risk per se and (4) patients with three aberrations in the absence of abnormalities of strong influence (hyperdiploid karyotype, t(9;11)(p21~22;q23), CBF-AML, unique adverse-risk aberrations) have borderline intermediate/adverse risk with a reduced overall survival compared with patients with a normal karyotype.

Authors with CRIS profile

Stefan Krause Department of Medicine 5 – Haematology and Oncology

Involved external institutions

Universitätsklinikum Würzburg DE Germany (DE) Technische Universität Dresden DE Germany (DE) Ruprecht-Karls-Universität Heidelberg DE Germany (DE) Masaryk University CZ Czech Republic (CZ) Universitätsklinikum Gießen und Marburg (UKGM) DE Germany (DE) Klinikum Chemnitz DE Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) DE Germany (DE) Asklepios Kliniken DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) Robert-Bosch-Krankenhaus DE Germany (DE) Universitätsklinikum Münster DE Germany (DE) Rems-Murr-Kliniken DE Germany (DE)

How to cite

APA:

Stoelzel, F., Mohr, B., Kramer, M., Oelschlaegel, U., Bochtler, T., Berdel, W.E.,... Ehninger, G. (2016). Karyotype complexity and prognosis in acute myeloid leukemia. Blood Cancer Journal, 6, e386. https://doi.org/10.1038/bcj.2015.114

MLA:

Stoelzel, F., et al. "Karyotype complexity and prognosis in acute myeloid leukemia." Blood Cancer Journal 6 (2016): e386.

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