Understanding critical illness myopathy: approaching the pathomechanism.
Friedrich O, Fink R, Hund E (2005)
Publication Status: Published
Publication Type: Journal article
Publication year: 2005
Journal
Publisher: American Society for Nutrition
Book Volume: 135
Pages Range: 1813S-1817S
Journal Issue: 7
Abstract
Myopathies occurring in critically ill patients have gained increasing interest during the past years. For the patient, they represent a crucial factor for prolonged intensive care unit treatment and secondary complications. Critical illness myopathies (CIMs) seem to be related to various pathogenic factors. Among those, the septic inflammatory response syndrome seems to play a major role. It has been suggested that, similar to sepsis-related multiorgan failure, CIM might be considered a failure of the organ muscle. Muscle function might be impaired by proposed "myotoxic" humoral factors. These could be endogenously produced during the innate immune response to sepsis. This article follows up recent evidence for such active fractions in the blood serum of CIM patients. To explain muscle weakness in CIM, serum fractions acutely modified membrane excitability and subcellular Ca2+ regulation in an animal model. From the differential serum effects, early-phase CIM seems to involve a reduction in the overall force generation in muscle but also a compensation by the membrane, increasing the excitability. Different animal models will help to elucidate the underlying mechanisms accounting for the specific proteolytic activities found in different forms of CIM. CIM represents a systemic rather than a local disorder. Humoral factors might initiate the local reaction of skeletal muscle clinically seen as muscle weakness, altered excitability, and proteolysis of contractile proteins. Establishing the interactions in the excitation-contraction cascade in CIM is a challenging task, not only to clarify its pathomechanism but also to deduce clinical interventions.
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APA:
Friedrich, O., Fink, R., & Hund, E. (2005). Understanding critical illness myopathy: approaching the pathomechanism. Journal of Nutrition, 135(7), 1813S-1817S. https://doi.org/10.1093/jn/135.7.1813S
MLA:
Friedrich, Oliver, Rainer Fink, and Ernst Hund. "Understanding critical illness myopathy: approaching the pathomechanism." Journal of Nutrition 135.7 (2005): 1813S-1817S.
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