Reinforcement of calcium phosphate cement with multi-walled carbon nanotubes and bovine serum albumin for injectable bone substitute applications

Chew KK, Low KL, Zein SHS, Mcphail DS, Gerhardt LC, Roether JA, Boccaccini AR (2011)

Publication Type: Journal article

Publication year: 2011

Journal

Journal of the Mechanical Behavior of Biomedical Materials Elsevier

Publisher: Elsevier

Pages Range: 331-339

Journal Issue: 4

DOI: 10.1016/j.jmbbm.2010.10.013

Abstract

This paper presents the development of novel alternative injectable calcium phosphate cement (CPC) composites for orthopaedic applications. The new CPC composites comprise β-tri-calcium phosphate (β-TCP) and di-calcium phosphate anhydrous (DCPA) mixed with bovine serum albumin (BSA) and incorporated with multi-walled carbon nanotubes (MWCNTs) or functionalized MWCNTs (MWCNTs-OH and MWCNTs-COOH). Scanning electron microscopy (SEM), compressive strength tests, injectability tests, Fourier transform infrared spectroscopy and X-ray diffraction were used to evaluate the properties of the final products. Compressive strength tests and SEM observations demonstrated particularly that the concomitant admixture of BSA and MWCNT improved the mechanical properties, resulting in stronger CPC composites. The presence of MWCNTs and BSA influenced the morphology of the hydroxyapatite (HA) crystals in the CPC matrix. BSA was found to act as a promoter of HA growth when bounded to the surface of CPC grains. MWCNT-OH-containing composites exhibited the highest compressive strengths (16.3 MPa), being in the range of values for trabecular bone (2-12 MPa). © 2010 Elsevier Ltd.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

University of Science Malaysia (USM) / Universiti Sains Malaysia MY Malaysia (MY) Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB)

How to cite

APA:

Chew, K.-K., Low, K.-L., Zein, S.H.S., Mcphail, D.S., Gerhardt, L.-C., Roether, J.A., & Boccaccini, A.R. (2011). Reinforcement of calcium phosphate cement with multi-walled carbon nanotubes and bovine serum albumin for injectable bone substitute applications. Journal of the Mechanical Behavior of Biomedical Materials, 4, 331-339. https://doi.org/10.1016/j.jmbbm.2010.10.013

MLA:

Chew, Kean-Khoon, et al. "Reinforcement of calcium phosphate cement with multi-walled carbon nanotubes and bovine serum albumin for injectable bone substitute applications." Journal of the Mechanical Behavior of Biomedical Materials 4 (2011): 331-339.

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