Ivanovic-Burmazovic I, Filipovic M (2012)
Publication Type: Authored book, other
Publication year: 2012
Original Authors: Ivanović-Burmazović I., Filipović M.
Publisher: Academic Press, Inc.
Book Volume: 64
Pages Range: 53-95
Journal Issue: null
DOI: 10.1016/B978-0-12-396462-5.00003-9
The (bio)chemistry and physiology of superoxide and nitric oxide and their interactions with metal centers are very complex issues, which require a multidisciplinary approach. We are still not fully aware of the reactions that occur in relatively simple . in vitro conditions and we know even less about the real processes on a molecular level under the . in vivo conditions. Systematic studies and reliable, comparable data on number of different manganese superoxide dismutase (MnSOD) mimetics, regarding their reactivity toward reactive oxygen and nitrogen species and corresponding reaction mechanisms, are required for the further progress in the field and possible biomedical application of the gained knowledge. We present here some important aspects of chemistry, in particular, redox activity, and biochemistry of superoxide and nitric oxide as well as their interaction with MnSOD mimetics that should be considered for the future design and pharmacological studies of manganese-based therapeutics and even diagnostic tools. © 2012 Elsevier Inc.
APA:
Ivanovic-Burmazovic, I., & Filipovic, M. (2012). Reactivity of manganese superoxide dismutase mimics toward superoxide and nitric oxide. Selectivity versus cross-reactivity. Academic Press, Inc..
MLA:
Ivanovic-Burmazovic, Ivana, and Milos Filipovic. Reactivity of manganese superoxide dismutase mimics toward superoxide and nitric oxide. Selectivity versus cross-reactivity. Academic Press, Inc., 2012.
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