Blockade of IL-36 Receptor Signaling Does Not Prevent from TNF-Induced Arthritis

Derer A, Groetsch B, Harre U, Böhm C, Towne J, Schett G, Frey S, Hueber A (2014)

Publication Type: Journal article

Publication year: 2014

Journal

PLoS ONE Public Library of Science

Book Volume: 9

Pages Range: e101954

Journal Issue: 8

DOI: 10.1371/journal.pone.0101954

Abstract

Interleukin (IL)-36? is a newly described member of the IL-1 cytokine family with a known inflammatory and pathogenic function in psoriasis. Recently, we could demonstrate that the receptor (IL-36R), its ligand IL-36? and its antagonist IL-36Ra are expressed in synovial tissue of arthritis patients. Furthermore, IL-36? induces MAP-kinase and NF?B signaling in human synovial fibroblasts with subsequent expression and secretion of pro-inflammatory cytokines.To understand the pathomechanism of IL-36 dependent inflammation, we investigated the biological impact of IL-36? signaling in the hTNFtg mouse. Also the impact on osteoclastogenesis by IL-36? was tested in murine and human osteoclast assays.Diseased mice showed an increased expression of IL-36R and IL-36? in inflamed knee joints compared to wildtype controls. However, preventively treating mice with an IL-36R blocking antibody led to no changes in clinical onset and pattern of disease. Furthermore, blockade of IL-36 signaling did not change histological signs of TNF-induced arthritis. Additionally, no alteration on bone homeostasis was observed in ex vivo murine and human osteoclast differentiation assays.Thus we conclude that IL-36? does not affect the development of inflammatory arthritis.

Authors with CRIS profile

Anja Derer Department of Radiation Oncology Ulrike Steffen Lehrstuhl für Genetik Christina Böhm Department of Medicine 3 – Rheumatology and Immunology Georg Schett Lehrstuhl für Innere Medizin III Silke Frey Department of Medicine 3 – Rheumatology and Immunology Axel Hueber Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Amgen Inc. US United States (USA) (US)

How to cite

APA:

Derer, A., Groetsch, B., Harre, U., Böhm, C., Towne, J., Schett, G.,... Hueber, A. (2014). Blockade of IL-36 Receptor Signaling Does Not Prevent from TNF-Induced Arthritis. PLoS ONE, 9(8), e101954. https://doi.org/10.1371/journal.pone.0101954

MLA:

Derer, Anja, et al. "Blockade of IL-36 Receptor Signaling Does Not Prevent from TNF-Induced Arthritis." PLoS ONE 9.8 (2014): e101954.

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