Quantification and impact of secondary osteoarthritis in patients with anti-citrullinated protein antibodies positive rheumatoid arthritis

Figueiredo CP, Simon D, Englbrecht M, Haschka J, Kleyer A, Bayat S, Hueber A, Pereira RMR, Rech J, Schett G (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Arthritis and Rheumatology Wiley

Book Volume: 68

Pages Range: 2114-21

Journal Issue: 9

DOI: 10.1002/art.39698

Abstract

To search for evidence of secondary osteoarthritis in patients with rheumatoid arthritis (RA) in a cross-sectional and longitudinal setting and to relate osteophyte formation to functional outcome.Anti-citrullinated protein antibody positive (ACPA+) RA patients underwent high-resolution peripheral quantitative computed tomography (HR-pQCT) of the hand. Cross-sectional and longitudinal measurements were performed. Number and size of osteophytes as well as bone erosions were documented. Relation of osteophytes to bone erosions and to demographic and disease specific data was evaluated by multiple logistic regression models.202 ACPA+ RA patients were enrolled in the cross-sectional and 77 subjects in the longitudinal analysis (interval: 1.5 years). The mean number and size of osteophytes was 1.3±2.3 and 9.4±23.9 mm³ respectively. Osteophyte number was significantly (p<0.001) correlated to erosion number and osteophyte size to erosion size (p<0.001). Moreover, presence and size of osteophytes were related to age (p<0.001), disease duration (p<0.001) and to function as measured by the health assessment questionnaire (HAQ). Multivariate regression analyses showed an independent association between osteophytes and erosions. In the longitudinal analysis the mean number (p=0.033) and size (p<0.001) of osteophytes significantly increased in RA patients during their disease course. Conclusion Age, disease duration and bone erosions are associated with osteophytes indicating development of secondary osteoarthritis in patients with RA. This article is protected by copyright. All rights reserved.

Authors with CRIS profile

Arnd Kleyer Department of Medicine 3 – Rheumatology and Immunology Axel Hueber Department of Medicine 3 – Rheumatology and Immunology Georg Schett Lehrstuhl für Innere Medizin III

Involved external institutions

University of São Paulo / Universidade de São Paulo (USP) BR Brazil (BR) St. Vincentius-Kliniken / ViDia Kliniken DE Germany (DE)

How to cite

APA:

Figueiredo, C.P., Simon, D., Englbrecht, M., Haschka, J., Kleyer, A., Bayat, S.,... Schett, G. (2016). Quantification and impact of secondary osteoarthritis in patients with anti-citrullinated protein antibodies positive rheumatoid arthritis. Arthritis and Rheumatology, 68(9), 2114-21. https://doi.org/10.1002/art.39698

MLA:

Figueiredo, Camille P., et al. "Quantification and impact of secondary osteoarthritis in patients with anti-citrullinated protein antibodies positive rheumatoid arthritis." Arthritis and Rheumatology 68.9 (2016): 2114-21.

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