PPARβ/δ: A master regulator of mesenchymal stem cell functions
Djouad F, Ipseiz N, Luz-Crawford P, Scholtysek C, Krönke G, Jorgensen C (2016)
Publication Type: Journal article
Publication year: 2016
Journal
DOI: 10.1016/j.biochi.2016.11.011
Abstract
Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of physiological and immunological processes. Recently, one of their members PPAR?/? has been identified as major player in the maintenance of bone homeostasis, by promoting Wnt signalling activity in osteoblast and mesenchymal stem cells (MSC). PPAR?/? not only controls the fate of MSC but also regulates their immunosuppressive properties by directly modulating their NF-?B activity. In this review, we discuss how the regulation of PPAR?/? provides an innovative strategy for an optimisation of MSC-based therapy.
Authors with CRIS profile
Involved external institutions
National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM)
France (FR)
Cardiff University
United Kingdom (GB)
Universidad de los Andes
Chile (CL)
France (FR)
Cardiff University
United Kingdom (GB)
Universidad de los Andes
Chile (CL)
How to cite
APA:
Djouad, F., Ipseiz, N., Luz-Crawford, P., Scholtysek, C., Krönke, G., & Jorgensen, C. (2016). PPARβ/δ: A master regulator of mesenchymal stem cell functions. Biochimie. https://doi.org/10.1016/j.biochi.2016.11.011
MLA:
Djouad, Farida, et al. "PPARβ/δ: A master regulator of mesenchymal stem cell functions." Biochimie (2016).
BibTeX: Download