Stamatiades EG, Tremblay ME, Bohm M, Crozet L, Bisht K, Kao D, Coelho C, Fan X, Yewdell WT, Davidson A, Heeger PS, Diebold S, Nimmerjahn F, Geissmann F (2016)
Publication Status: Published
Publication Type: Journal article
Publication year: 2016
Publisher: Elsevier (Cell Press)
Book Volume: 166
Pages Range: 991-1003
Journal Issue: 4
DOI: 10.1016/j.cell.2016.06.058
Small immune complexes cause type III hypersensitivity reactions that frequently result in tissue injury. The responsible mechanisms, however, remain unclear and differ depending on target organs. Here, we identify a kidney-specific anatomical and functional unit, formed by resident macrophages and peritubular capillary endothelial cells, which monitors the transport of proteins and particles ranging from 20 to 700 kDa or 10 to 200 nm into the kidney interstitium. Kidney-resident macrophages detect and scavenge circulating immune complexes "pumped'' into the interstitium via trans-endothelial transport and trigger a Fc gamma RIV-dependent inflammatory response and the recruitment of monocytes and neutrophils. In addition, Fc gamma RIV and TLR pathways synergistically "super-activate'' kidney macrophages when immune complexes contain a nucleic acid. These data identify a physiological function of tissue-resident kidney macrophages and a basic mechanism by which they initiate the inflammatory response to small immune complexes in the kidney.
APA:
Stamatiades, E.G., Tremblay, M.-E., Bohm, M., Crozet, L., Bisht, K., Kao, D.,... Geissmann, F. (2016). Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages. Cell, 166(4), 991-1003. https://doi.org/10.1016/j.cell.2016.06.058
MLA:
Stamatiades, Efstathios G., et al. "Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages." Cell 166.4 (2016): 991-1003.
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