Emerging Histopathological and Genetic Parameters of Pituitary Adenomas: Clinical Impact and Recommendation for Future WHO Classification

Saeger W, Petersenn S, Schöfl C, Knappe UJ, Theodoropoulou M, Buslei R, Honegger J (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Endocrine Pathology Humana Press

Book Volume: 27

Pages Range: 115-22

Journal Issue: 2

DOI: 10.1007/s12022-016-9419-6

Abstract

The review assesses immunohistochemical findings of somatostatin receptors and of metalloproteinases in different pituitary adenoma types and the significance of molecular genetic data. Current evidence does not support routine immunohistochemical assessment of somatostatin or dopamine receptor subtype expression on hormone-secreting or nonfunctioning pituitary adenomas. Further prospective studies are needed to define its role for clinical decision making. Until then we suggest to restrict membrane receptor profiling to individual cases or for study purposes. The problems of adenoma expansion and invasion are discussed. Despite partially contradictory publications, proteases clearly play a major role in permission of infiltrative growth of pituitary adenomas. Therefore, detection of at least MMP-2, MMP-9, TIMP-2, and uPA seems to be justified. Molecular characterization is important for familial adenomas, adenomas in MEN, Carney complex, and McCune-Albright syndrome and can gain insight into pathogenesis of sporadic adenomas.

Authors with CRIS profile

Christof Schöfl Professur für Endokrinologie

Involved external institutions

Eberhard Karls Universität Tübingen DE Germany (DE) ENDOC Praxis für Endokrinologie, Andrologie und medikamentöse Tumortherapie DE Germany (DE) Johannes Wesling Klinikum Minden DE Germany (DE) Max-Planck-Institut für Psychiatrie (Deutsche Forschungsanstalt für Psychiatrie) DE Germany (DE) Universität Hamburg (UHH) DE Germany (DE)

How to cite

APA:

Saeger, W., Petersenn, S., Schöfl, C., Knappe, U.J., Theodoropoulou, M., Buslei, R., & Honegger, J. (2016). Emerging Histopathological and Genetic Parameters of Pituitary Adenomas: Clinical Impact and Recommendation for Future WHO Classification. Endocrine Pathology, 27(2), 115-22. https://doi.org/10.1007/s12022-016-9419-6

MLA:

Saeger, W., et al. "Emerging Histopathological and Genetic Parameters of Pituitary Adenomas: Clinical Impact and Recommendation for Future WHO Classification." Endocrine Pathology 27.2 (2016): 115-22.

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