Development of a new classification for in vivo diagnosis of duodenal epithelial tumors with confocal laser endomicroscopy: A pilot study

Nonaka K, Ohata K, Ichihara S, Ban S, Hiejima Y, Minato Y, Tashima T, Matsuyama Y, Takita M, Matsuhashi N, Takasugi R, Neumann H (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Digestive Endoscopy Wiley-Blackwell

Book Volume: 28

Pages Range: 186-93

Journal Issue: 2

DOI: 10.1111/den.12564

Abstract

Confocal laser endomicroscopy (CLE) has been established for in vivo diagnosis of various gastrointestinal diseases. However, validated criteria for confocal diagnosis of duodenal tumors do not exist. Therefore, the aim of the present pilot study was to develop a novel classification for in vivo optical diagnosis of duodenal tumors using CLE.Consecutive patients with duodenal tumorous lesions were included. First, an initial classification system was developed which was then validated. Histopathology was used as a reference standard.A simple classification system for in vivo diagnosis of duodenal epithelial tumors using CLE was developed. Sensitivity, specificity, and accuracy were 90%, 100%, and 97%, respectively. Positive and negative predictive values were calculated as 100% and 96%. The kappa coefficient representing consistency was 1 between observers and within each observer.A new classification for in vivo diagnosis of duodenal epithelial tumors using confocal imaging has been developed. The new classification system allows adequate prediction of histology and could therefore be used to guide subsequent therapy of duodenal lesions.

Involved external institutions

Nippon Telegraph and Telephone (NTT) / 日本電信電話株式会社 JP Japan (JP) Sapporo-Kosei General Hospital / JA北海道厚生連札幌厚生病院 JP Japan (JP) Dokkyo Medical University JP Japan (JP) Tokyo Health Care University JP Japan (JP)

How to cite

APA:

Nonaka, K., Ohata, K., Ichihara, S., Ban, S., Hiejima, Y., Minato, Y.,... Neumann, H. (2016). Development of a new classification for in vivo diagnosis of duodenal epithelial tumors with confocal laser endomicroscopy: A pilot study. Digestive Endoscopy, 28(2), 186-93. https://doi.org/10.1111/den.12564

MLA:

Nonaka, Kouichi, et al. "Development of a new classification for in vivo diagnosis of duodenal epithelial tumors with confocal laser endomicroscopy: A pilot study." Digestive Endoscopy 28.2 (2016): 186-93.

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