The effect of renal denervation in moderate treatment-resistant hypertension with confirmed medication adherence

Ott C, Mahfoud F, Schmid A, Ewen S, Toennes SW, Meyer MR, Helfer AG, Maurer HH, Ditting T, Veelken R, Zivanovic I, Uder M, Boehm M, Schmieder R (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Book Volume: 34

Pages Range: 2475-2479

Journal Issue: 12

DOI: 10.1097/HJH.0000000000001110

Abstract

Data on the blood pressure (BP)-lowering effect of renal denervation (RDN) in moderate treatment-resistant hypertension (TRH) are limited. Moreover, change of adherence to medication, as one potential confounder of BP response, has never been analyzed rigorously in this group of patients. We analyzed the effect of RDN on BP in patients with moderate TRH who were retrospectively found to be completely adherent to their antihypertensive medication.Our study cohort comprised 40 patients with moderate TRH [office BP >= 140/90 but <160/100 mmHg and 24-h ambulatory BP monitoring (ABPM) >=130/80 mmHg] who underwent catheter-based RDN. Further major inclusion criterion was complete adherence to their medication (>=80% intake of their prescribed antihypertensive drugs) at baseline (assessed by retrospective toxicological analysis).Six months after RDN, office BP was reduced by -10/-6 mmHg (SBP: 149 ± 6 vs. 139 ± 15 mmHg; DBP: 81 ± 12 vs. 75 ± 10 mmHg; both P < 0.001) and 24-h ABPM by -7/-4 mmHg (SBP: 150 ± 14 vs. 143 ± 16 mmHg, P = 0.005; DBP: 82 ± 10 vs. 78 ± 9 mmHg, P = 0.009). Number of prescribed antihypertensive medication [6.0 (5.0-6.0) vs. 5.5 (5.0-6.0), P = 0.013] and adherence rate (95.2 ± 7.6 vs. 91.7 ± 13.9%, P = 0.065) was slightly reduced 6 months after RDN, both likely to underestimate the true BP reduction.Thus, our data indicate that even after given full respect to drug adherence as potential confounder of BP response after RDN, both office and 24-h ABPM were substantially reduced in patients with moderate TRH.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum des Saarlandes (UKS) Germany (DE) Universität des Saarlandes (UdS) Germany (DE) Goethe-Universität Frankfurt am Main Germany (DE)

How to cite

APA:

Ott, C., Mahfoud, F., Schmid, A., Ewen, S., Toennes, S.W., Meyer, M.R.,... Schmieder, R. (2016). The effect of renal denervation in moderate treatment-resistant hypertension with confirmed medication adherence. Journal of Hypertension, 34(12), 2475-2479. https://doi.org/10.1097/HJH.0000000000001110

MLA:

Ott, Christian, et al. "The effect of renal denervation in moderate treatment-resistant hypertension with confirmed medication adherence." Journal of Hypertension 34.12 (2016): 2475-2479.

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