Critical role of spatial interaction between CD8? and Foxp3? cells in human gastric cancer: the distance matters
Feichtenbeiner A, Haas M, Büttner M, Grabenbauer G, Fietkau R, Distel L (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: Springer Verlag (Germany)
Book Volume: 63
Pages Range: 111-9
Journal Issue: 2
DOI: 10.1007/s00262-013-1491-x
Abstract
In various cancer types, an abundance of FoxP3(+) regulatory T cells (Treg) has been associated with an unfavorable outcome. Yet, the role of Treg on cancer immunity has been shown to be complex. In single cell marker technique, other tumor-infiltrating lymphocytes (TILs) such as cytotoxic CD8(+) T cells (CTL) also influenced prognosis. This study for the first time investigates the concurrent spatial distribution pattern of CD8(+) and FoxP3(+) TILs and their prognostic impact in human gastric cancer.Tumor tissue microarrays of 50 patients with surgically treated adenocarcinoma of the cardia were studied. An immunohistochemical double staining of CD8(+) and FoxP3(+) TILs was performed. Cell counts and cell-to-cell distances in tumor epithelium and stroma were evaluated with image-processing software. Metastasis-free survival, no-evidence-of-disease survival, and overall survival were investigated (mean follow-up time 6.9 years).High intraepithelial infiltration of CD8(+) and FoxP3(+) TIL was associated with the improved 10-year metastasis-free survival (83 vs. 54%, p = 0.04 and 85 vs. 59%, p = 0.09, respectively). Considering cell-to-cell distance and comparing patients with functional (30-110 ?m) versus nonfunctional distances of CD8(+) and FoxP3(+) TILs, 10-year survival rates differed between 89 and 55% (p = 0.009), respectively.Prognostic influence of tumor-infiltrating immune cells in gastric cancer critically depends on their cell-to-cell distance. FoxP3(+) TILs must be located within a distance between 30 and 110 ?m of CD8(+) T cells to positively impact on prognosis.
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APA:
Feichtenbeiner, A., Haas, M., Büttner, M., Grabenbauer, G., Fietkau, R., & Distel, L. (2014). Critical role of spatial interaction between CD8? and Foxp3? cells in human gastric cancer: the distance matters. Cancer Immunology Immunotherapy, 63(2), 111-9. https://doi.org/10.1007/s00262-013-1491-x
MLA:
Feichtenbeiner, Anita, et al. "Critical role of spatial interaction between CD8? and Foxp3? cells in human gastric cancer: the distance matters." Cancer Immunology Immunotherapy 63.2 (2014): 111-9.
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