Clinical remission in rheumatoid arthritis : Data from the early arthritis cohort study CAPEA

Albrecht K, Callhoff J, Edelmann E, Schett G, Schneider M, Zink A (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Zeitschrift für Rheumatologie Springer Verlag

Book Volume: 75

Pages Range: 90-6

Journal Issue: 1

DOI: 10.1007/s00393-015-0019-5

Abstract

To evaluate remission rates and therapeutic strategies in the routine care of early rheumatoid arthritis.Between 2010 and 2013, a total of 1,301 patients with early arthritis were followed by 89 rheumatologists for up to 2 years in an early arthritis cohort (CAPEA). Complete 2-year data are available for 669 patients with rheumatoid arthritis.Ninety-three percent of patients were diagnosed with a moderate or high disease activity score (DAS28 > 3.2). Within 6 months, 40 % were in clinical remission (DAS28 < 2.6) and 21 % reached a low disease activity score (DAS28 > 2.6 to < 3.2). This proportion did not substantially increase during the 2-year follow-up. Methotrexate was the standard first-line treatment in 82 % of patients. During follow-up, 10 % were treated with a combination of disease-modifying antirheumatic drugs (DMARDs) and 12 % with biological agents. In 60 % of the patients who did not reach remission within 3 months (and 54 % of patients without remission by 6 months), treatment was not changed. At the beginning, 77 % of patients were treated with glucocorticoids at different starting doses (26 % < 7.5 mg, 29 % 7.5-20 mg, and 45 % >= 20 mg of prednisolone per day). After 2 years, 47 % remained on glucocorticoids.While 40 % of patients achieved clinical remission through standard care within 6 months, disease activity remained moderate to high in 37 % of patients at 2 years. In these patients a more consistent application of treatment may have increased the response rates.

Authors with CRIS profile

Georg Schett Lehrstuhl für Innere Medizin III

Involved external institutions

Deutsches Rheuma-Forschungszentrum (DRFZ) DE Germany (DE) Rheumazentrum Bad Aibling & Erding DE Germany (DE) Heinrich-Heine-Universität Düsseldorf DE Germany (DE)

How to cite

APA:

Albrecht, K., Callhoff, J., Edelmann, E., Schett, G., Schneider, M., & Zink, A. (2016). Clinical remission in rheumatoid arthritis : Data from the early arthritis cohort study CAPEA. Zeitschrift für Rheumatologie, 75(1), 90-6. https://doi.org/10.1007/s00393-015-0019-5

MLA:

Albrecht, K., et al. "Clinical remission in rheumatoid arthritis : Data from the early arthritis cohort study CAPEA." Zeitschrift für Rheumatologie 75.1 (2016): 90-6.

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