Wunderlich C, Oliviera I, Figueiredo CP, Rech J, Schett G (2016)
Publication Type: Journal article
Publication year: 2016
DOI: 10.1016/j.semarthrit.2016.09.011
To study whether stable treatment with DMARDs affects anti-CCP2 antibody levels in patients with rheumatoid arthritis.In this longitudinal observational study 100 RA patients were followed for anti-CCP2 IgG antibody (U/L) and total IgG level (mg/dL) every 6 months for a total period of 2.5 years. All patients received stable DMARD treatment during this period. Five groups comprising each 20 patients were analyzed as follows: (1) methotrexate (MTX) alone, (2) tumor necrosis factor inhibitors (TNFi), (3) tocilizumab (TCZ), (4) rituximab (RTX), and (5) abatacept (ABA).Baseline demographic and disease-specific characteristics were comparable between the 5 groups. Anti-CCP2 antibody levels did not show significant changes in patients treated with MTX (mean ± SEM: -24.1 ± 8.1%), TNFi (-14.0 ± 11.1%) or TCZ (-24.3 ± 11.3%) between baseline and the 2.5 years follow-up. In contrast, anti-CCP2 antibody levels significantly decreased during treatment with RTX (-75.6 ± 4.4%) and ABA (-82.5 ± 3.7%). With respect to total IgG levels, no significant changes were observed with MTX (-1.6 ± 3.5%), TNFi (2.5 ± 3.4%), TCZ (-4.4 ± 3.1%), or ABA (-2.4 ± 3.8%) over 2.5 years. In contrast, total IgG levels significantly decreased during treatment with RTX (-22.0 ± 3.7%).DMARDs targeting the adaptive immune response such as ABA and RTX significantly lowered anti-CCP2 IgG levels, while cytokine inhibitors and methotrexate had no significant effects on anti-CCP2 IgG levels. RTX is the only DMARD, which also lowers total IgG level.
APA:
Wunderlich, C., Oliviera, I., Figueiredo, C.P., Rech, J., & Schett, G. (2016). Effects of DMARDs on citrullinated peptide autoantibody levels in RA patients-A longitudinal analysis. Seminars in Arthritis and Rheumatism. https://doi.org/10.1016/j.semarthrit.2016.09.011
MLA:
Wunderlich, Carolin, et al. "Effects of DMARDs on citrullinated peptide autoantibody levels in RA patients-A longitudinal analysis." Seminars in Arthritis and Rheumatism (2016).
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