Single molecule atomic force microscopy studies of photosensitized singlet oxygen behavior on a DNA origami template

Helmig S, Rotaru A, Arian D, Kovbasyuk L, Arnbjerg J, Ogilby PR, Kjems J, Mokhir A, Besenbacher F, Gothelf KV (2010)

Publication Type: Journal article, Original article

Publication year: 2010

Journal

Acs Nano American Chemical Society

Original Authors: Helmig S., Rotaru A., Arian D., Kovbasyuk L., Arnbjerg J., Ogilby P.R., Kjems J., Mokhir A., Besenbacher F., Gothelf K.V.

Publisher: American Chemical Society

Book Volume: 4

Pages Range: 7475-7480

Journal Issue: 12

DOI: 10.1021/nn102701f

Abstract

DNA origami, the folding of a long single-stranded DNA sequence (scaffold strand) by hundreds of short synthetic oligonucleotides (staple strands) into parallel aligned helices, is a highly efficient method to form advanced self-assembled DNA-architectures. Since molecules and various materials can be conjugated to each of the short staple strands, the origami method offers a unique possibility of arranging molecules and materials in well-defined positions on a structured surface. Here we combine the action of light with AFM and DNA nanostructures to study the production of singlet oxygen from a single photosensitizer molecule conjugated to a selected DNA origami staple strand on an origami structure. We demonstrate a distance-dependent oxidation of organic moieties incorporated in specific positions on DNA origami by singlet oxygen produced from a single photosensitizer located at the center of each origami. © 2010 American Chemical Society.

Authors with CRIS profile

Andriy Mokhir Professur für Organische Chemie

Involved external institutions

Aarhus University DK Denmark (DK) Ruprecht-Karls-Universität Heidelberg DE Germany (DE)

How to cite

APA:

Helmig, S., Rotaru, A., Arian, D., Kovbasyuk, L., Arnbjerg, J., Ogilby, P.R.,... Gothelf, K.V. (2010). Single molecule atomic force microscopy studies of photosensitized singlet oxygen behavior on a DNA origami template. Acs Nano, 4(12), 7475-7480. https://doi.org/10.1021/nn102701f

MLA:

Helmig, Sarah, et al. "Single molecule atomic force microscopy studies of photosensitized singlet oxygen behavior on a DNA origami template." Acs Nano 4.12 (2010): 7475-7480.

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