Jumar A, Harazny JM, Ott C, Friedrich S, Kistner I, Striepe K, Schmieder R (2016)
Publication Type: Journal article
Publication year: 2016
Book Volume: 11
Pages Range: e0162608
Journal Issue: 12
DOI: 10.1371/journal.pone.0162608
In diabetes mellitus type 2, capillary rarefaction plays a pivotal role in the pathogenesis of end-organ damage. We investigated retinal capillary density in patients with early disease.This cross-sectional study compares retinal capillary rarefaction determined by intercapillary distance (ICD) and capillary area (CapA), measured non-invasively and in vivo by scanning laser Doppler flowmetry, in 73 patients with type 2 diabetes, 55 healthy controls and 134 individuals with hypertension stage 1 or 2.In diabetic patients, ICD was greater (23.2±5.5 vs 20.2±4.2, p = 0.013) and CapA smaller (1592±595 vs 1821±652, p = 0.019) than in healthy controls after adjustment for differences in cardiovascular risk factors between the groups. Compared to hypertensive patients, diabetic individuals showed no difference in ICD (23.1±5.8, p = 0.781) and CapA (1556±649, p = 0.768).In the early stage of diabetes type 2, patients showed capillary rarefaction compared to healthy individuals.
APA:
Jumar, A., Harazny, J.M., Ott, C., Friedrich, S., Kistner, I., Striepe, K., & Schmieder, R. (2016). Retinal Capillary Rarefaction in Patients with Type 2 Diabetes Mellitus. PLoS ONE, 11(12), e0162608. https://doi.org/10.1371/journal.pone.0162608
MLA:
Jumar, Agnes, et al. "Retinal Capillary Rarefaction in Patients with Type 2 Diabetes Mellitus." PLoS ONE 11.12 (2016): e0162608.
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