Gulbins E, Walter S, Becker KA, Halmer R, Liu Y, Reichel M, Edwards MJ, Müller CP, Fassbender K, Kornhuber J (2015)
Publication Type: Journal article
Publication year: 2015
Book Volume: 134
Pages Range: 183-92
Journal Issue: 2
DOI: 10.1111/jnc.13145
Major depressive disorder is a severe and chronic illness with high lifetime prevalence and a high incidence of suicide as the cause of death for patients with this diagnosis. Major depressive disorder is often treated with anti-depressants. Although these drugs have been used for many years, their exact mode of action is still unknown. It has been suggested that many anti-depressants act by increasing the concentrations of serotonergic transmitters in the synaptic space. However, recent studies have examined the effects of anti-depressants on neurogenesis in the hippocampus, the restoration of hippocampal neuronal networks that may be affected by major depression, and the regulation of the hypothalamic-pituitary-adrenal axis by immature neurons in the hippocampus. Here, we present and discuss a novel hypothesis suggesting that these events are regulated by the concentrations of sphingolipids, in particular ceramide, in the hippocampus. These concepts suggest that the acid sphingomyelinase/ceramide system plays a central role in the pathogenesis of major depression and may be a novel target for anti-depressants.
APA:
Gulbins, E., Walter, S., Becker, K.A., Halmer, R., Liu, Y., Reichel, M.,... Kornhuber, J. (2015). A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression. Journal of Neurochemistry, 134(2), 183-92. https://doi.org/10.1111/jnc.13145
MLA:
Gulbins, Erich, et al. "A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression." Journal of Neurochemistry 134.2 (2015): 183-92.
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