Miyoshi T, Osawa K, Ito H, Kanazawa S, Kimura T, Shiomi H, Kuribayashi S, Jinzaki M, Kawamura A, Bezerra H, Achenbach S, Norgaard BL (2015)
Publication Type: Journal article
Publication year: 2015
Book Volume: 79
Pages Range: 406-12
Journal Issue: 2
Recently, a non-invasive method using computational fluid dynamics to calculate vessel-specific fractional flow reserve (FFRCT) from routinely acquired coronary computed tomography angiography (CTA) was described. The Analysis of Coronary Blood Flow Using CT Angiography: Next Steps (NXT) trial, which was a prospective, multicenter trial including 254 patients with suspected coronary artery disease, noted high diagnostic performance of FFRCT compared with invasive FFR. The aim of this post-hoc analysis was to assess the diagnostic performance of non-invasive FFRCT vs. standard stenosis quantification on coronary CTA in the Japanese subset of the NXT trial.A total of 57 Japanese participants were included from Okayama University (n=36), Kyoto University (n=17), and Keio University (n=4) Hospitals. Per-patient diagnostic accuracy of FFRCT(74%; 95% confidence interval [CI]: 60-85%) was higher than for coronary CTA (47%; 95% CI: 34-61%, P<0.001) arising from improved specificity (63% vs. 27%, P<0.001). FFRCT correctly reclassified 53% of patients and 63% of vessels with coronary CTA false positives as true negatives. When patients with Agatston score >1,000 were excluded, per-patient accuracy of FFRCT was 83% with a high specificity of 76%, similar to the overall NXT trial findings.FFRCT has high diagnostic performance compared with invasive FFR in the Japanese subset of patients in the NXT trial.
APA:
Miyoshi, T., Osawa, K., Ito, H., Kanazawa, S., Kimura, T., Shiomi, H.,... Norgaard, B.L. (2015). Non-invasive computed fractional flow reserve from computed tomography (CT) for diagnosing coronary artery disease - Japanese results from NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). Circulation Journal, 79(2), 406-12. https://doi.org/10.1253/circj.CJ-14-1051
MLA:
Miyoshi, Toru, et al. "Non-invasive computed fractional flow reserve from computed tomography (CT) for diagnosing coronary artery disease - Japanese results from NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps)." Circulation Journal 79.2 (2015): 406-12.
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