Geisberger S, Maschke U, Gebhardt M, Kleinewietfeld M, Manzel A, Linker R, Chidgey A, Dechend R, Nguyen G, Daumke O, Muller DN, Wright MD, Binger KJ (2015)
Publication Type: Journal article
Publication year: 2015
Book Volume: 126
Pages Range: 504-7
Journal Issue: 4
DOI: 10.1182/blood-2015-03-635292
The (pro)renin receptor (PRR) was originally thought to be important for regulating blood pressure via the renin-angiotensin system. However, it is now emerging that PRR has instead a generic role in cellular development. Here, we have specifically deleted PRR from T cells. T-cell-specific PRR-knockout mice had a significant decrease in thymic cellularity, corresponding with a 100-fold decrease in the number of CD4(+) and CD8(+) thymocytes, and a large increase in double-negative (DN) precursors. Gene expression analysis on sorted DN3 thymocytes indicated that PRR-deficient thymocytes have perturbations in key cellular pathways essential at the DN3 stage, including transcription and translation. Further characterization of DN T-cell progenitors leads us to propose that PRR deletion affects thymocyte survival and development at multiple stages; from DN3 through to DN4, double-positive, and single-positive CD4 and CD8. Our study thus identifies a new role for PRR in T-cell development.
APA:
Geisberger, S., Maschke, U., Gebhardt, M., Kleinewietfeld, M., Manzel, A., Linker, R.,... Binger, K.J. (2015). New role for the (pro)renin receptor in T-cell development. Blood, 126(4), 504-7. https://doi.org/10.1182/blood-2015-03-635292
MLA:
Geisberger, Sabrina, et al. "New role for the (pro)renin receptor in T-cell development." Blood 126.4 (2015): 504-7.
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