Renal impairment and worsening of renal function in acute heart failure: can new therapies help? The potential role of serelaxin

Schmieder R, Mitrovic V, Hengstenberg C (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Clinical Research in Cardiology Springer Verlag (Germany)

Book Volume: 104

Pages Range: 621-31

Journal Issue: 8

DOI: 10.1007/s00392-015-0839-y

Abstract

Renal dysfunction is a frequent finding in patients with acute heart failure (AHF) and an important prognostic factor for adverse outcomes. Worsening of renal function occurs in 30-50 % of patients hospitalised for AHF, and is associated with increased mortality, prolonged hospital stay and increased risk of readmission. Likely mechanisms involved in the decrease in renal function include impaired haemodynamics and activation of neurohormonal factors, such as the renin-angiotensin-aldosterone system, the sympathetic nervous system and the arginine-vasopressin system. Additionally, many drugs currently used to treat AHF have a detrimental effect on renal function. Therefore, pharmacotherapy for AHF should carefully take into account any potential complications related to renal function. Serelaxin, currently in clinical development for the treatment of AHF is a recombinant form of human relaxin-2, identical in structure to the naturally occurring human relaxin-2 peptide hormone that mediates cardiac and renal adaptations during pregnancy. Data from both pre-clinical and clinical studies indicate a potentially beneficial effect of serelaxin on kidney function. In this review, we discuss the mechanisms and impact of impairment of renal function in AHF, and the potential benefits of new therapies, such as serelaxin, in this context.

Authors with CRIS profile

Roland Schmieder Professur für Innere Medizin (Nephrologie)

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) Max Planck Institute for Heart and Lung Research / Max-Planck-Institut für Herz- und Lungenforschung DE Germany (DE)

How to cite

APA:

Schmieder, R., Mitrovic, V., & Hengstenberg, C. (2015). Renal impairment and worsening of renal function in acute heart failure: can new therapies help? The potential role of serelaxin. Clinical Research in Cardiology, 104(8), 621-31. https://doi.org/10.1007/s00392-015-0839-y

MLA:

Schmieder, Roland, Veselin Mitrovic, and Christian Hengstenberg. "Renal impairment and worsening of renal function in acute heart failure: can new therapies help? The potential role of serelaxin." Clinical Research in Cardiology 104.8 (2015): 621-31.

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