Myeloid Cell-Derived HIF-1? Promotes Control of Leishmania major

Schatz V, Strussmann Y, Mahnke A, Schley G, Waldner M, Ritter U, Wild J, Willam C, Dehne N, Brune B, Mcniff JM, Colegio OR, Bogdan C, Jantsch J (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Journal of Immunology American Association of Immunologists

Book Volume: 197

Pages Range: 4034-4041

Journal Issue: 10

DOI: 10.4049/jimmunol.1601080

Abstract

Hypoxia-inducible factor-1? (HIF-1?), which accumulates in mammalian host organisms during infection, supports the defense against microbial pathogens. However, whether and to what extent HIF-1? expressed by myeloid cells contributes to the innate immune response against Leishmania major parasites is unknown. We observed that Leishmania-infected humans and L. major-infected C57BL/6 mice exhibited substantial amounts of HIF-1? in acute cutaneous lesions. In vitro, HIF-1? was required for leishmanicidal activity and high-level NO production by IFN-?/LPS-activated macrophages. Mice deficient for HIF-1? in their myeloid cell compartment had a more severe clinical course of infection and increased parasite burden in the skin lesions compared with wild-type controls. These findings were paralleled by reduced expression of type 2 NO synthase by lesional CD11b(+) cells. Together, these data illustrate that HIF-1? is required for optimal innate leishmanicidal immune responses and, thereby, contributes to the cure of cutaneous leishmaniasis.

Authors with CRIS profile

Alexander Mahnke Lehrstuhl für Mikrobiologie und Infektionsimmunologie Maximilian Waldner Lehrstuhl für Innere Medizin I Carsten Willam Department of Medicine 4 – Nephrology and Hypertension Christian Bogdan Lehrstuhl für Mikrobiologie und Infektionsimmunologie

Involved external institutions

Universität Regensburg DE Germany (DE) Goethe-Universität Frankfurt am Main DE Germany (DE) Yale University US United States (USA) (US)

How to cite

APA:

Schatz, V., Strussmann, Y., Mahnke, A., Schley, G., Waldner, M., Ritter, U.,... Jantsch, J. (2016). Myeloid Cell-Derived HIF-1? Promotes Control of Leishmania major. Journal of Immunology, 197(10), 4034-4041. https://doi.org/10.4049/jimmunol.1601080

MLA:

Schatz, Valentin, et al. "Myeloid Cell-Derived HIF-1? Promotes Control of Leishmania major." Journal of Immunology 197.10 (2016): 4034-4041.

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