A subset of human plasmacytoid dendritic cells expresses CD8? upon exposure to herpes simplex virus type 1

Schuster P, Thomann S, Werner M, Vollmer J, Schmidt B (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Frontiers in Microbiology Frontiers Media

Book Volume: 6

Pages Range: 557

DOI: 10.3389/fmicb.2015.00557

Abstract

Classical and plasmacytoid dendritic cells (DC) play important roles in the defense against murine and human infections with herpes simplex virus (HSV). So far, CD8? expression has only been reported for murine DC. CD8?(+) DC have prominent cross-presenting activities, which are enhanced by murine CD8?(+) PDC. The human orthologue of murine CD8?(+) DC, the CD141 (BDCA3)(+) DC, mainly cross-present after TLR3 ligation. We report here the serendipitous finding that a subset of human PDC upregulates CD8? upon HSV-1 stimulation, as shown by gene array and flow cytometry analyses. CD8?, not CD8ß, was expressed upon exposure. Markers of activation, migration, and costimulation were upregulated on CD8?-expressing human PDC. In these cells, increased cytokine and chemokine levels were detected that enhance development and function of T, B, and NK cells, and recruit immature DC, monocytes, and Th1 cells, respectively. Altogether, human CD8?(+) PDC exhibit a highly activated phenotype and appear to recruit other immune cells to the site of inflammation. Further studies will show whether CD8?-expressing PDC contribute to antigen cross-presentation, which may be important for immune defenses against HSV infections in vitro and in vivo.

Authors with CRIS profile

Sabrina Thomann Department of Molecular Immunology

Involved external institutions

Universität Regensburg DE Germany (DE) Nexigen GmbH DE Germany (DE)

How to cite

APA:

Schuster, P., Thomann, S., Werner, M., Vollmer, J., & Schmidt, B. (2015). A subset of human plasmacytoid dendritic cells expresses CD8? upon exposure to herpes simplex virus type 1. Frontiers in Microbiology, 6, 557. https://doi.org/10.3389/fmicb.2015.00557

MLA:

Schuster, Philipp, et al. "A subset of human plasmacytoid dendritic cells expresses CD8? upon exposure to herpes simplex virus type 1." Frontiers in Microbiology 6 (2015): 557.

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