Wachter D (2016)
Publication Type: Journal article
Publication year: 2016
Book Volume: 37
Pages Range: 217-222
Journal Issue: Suppl 2
DOI: 10.1007/s00292-016-0210-8
Breast cancer can be divided into four molecular subtypes with different prognoses using immunohistochemical markers in the routine clinicopathological work-up. The protein Ki-67 is of central importance in this context, in particular to distinguish between luminal A and luminal B carcinomas. Determination of the Ki-67 index of a carcinoma also allows a prediction of the likelihood of the response to chemotherapy. Additionally, the expression of certain cytokeratins in tumor cells is associated with a poor response to chemotherapy. The heterogeneity of molecular subtypes with regard to the histological appearance indicates an even greater diversity of breast cancer. We were able to show that a high proportion of luminal B carcinomas display neuroendocrine differentiation. Further studies with particular emphasis on histomorphological criteria should be performed to attain a more accurate classification of breast cancer and to pave the way towards targeted therapies for a better prognosis in the future.
APA:
Wachter, D. (2016). New prognostic and predictive markers for breast cancer. Pathologe, 37(Suppl 2), 217-222. https://doi.org/10.1007/s00292-016-0210-8
MLA:
Wachter, David. "New prognostic and predictive markers for breast cancer." Pathologe 37.Suppl 2 (2016): 217-222.
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