Stem Cell Aging and Age-Related Cardiovascular Disease: Perspectives of Treatment by Ex-vivo Stem Cell Rejuvenation
Madonna R, Engel F, Davidson SM, Ferdinandy P, Goerbe A, Sluijter JPG, Van Laake LW (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 16
Pages Range: 780-5
Journal Issue: 8
Abstract
Aging affects endogenous stem cells in terms of functionality and numbers. In particular, during aging, the stemness property can decrease because of enhanced apoptotic cell death and senescence. In addition, aging and aging-related co-morbidities affect the paracrine activity of stem cells and the efficiency of their transplantation. Collectively, this leads to a reduction of the capacity of organs to repair themselves, possibly due to a reduced functional capability of stem cells. Therefore, major efforts have been invested to improve the repair capability of stem cells in aged individuals by overexpressing antisenescence and antiapoptotic genes. In this review, we describe critical genes and signaling pathways in stem cell aging and discuss ex vivo genetic modification approaches aimed at stem cell rejuvenation that are of interest for the cardiovascular system.
Authors with CRIS profile
Involved external institutions
University Medical Centre Utrecht (UMC Utrecht)
Netherlands (NL)
Pharmahungary Group
Hungary (HU)
Semmelweis University / Semmelweis Egyetem
Hungary (HU)
University College London (UCL)
United Kingdom (GB)
Università degli Studi Gabriele D'Annunzio
Italy (IT)
Netherlands (NL)
Pharmahungary Group
Hungary (HU)
Semmelweis University / Semmelweis Egyetem
Hungary (HU)
University College London (UCL)
United Kingdom (GB)
Università degli Studi Gabriele D'Annunzio
Italy (IT)
How to cite
APA:
Madonna, R., Engel, F., Davidson, S.M., Ferdinandy, P., Goerbe, A., Sluijter, J.P.G., & Van Laake, L.W. (2015). Stem Cell Aging and Age-Related Cardiovascular Disease: Perspectives of Treatment by Ex-vivo Stem Cell Rejuvenation. Current Drug Targets, 16(8), 780-5.
MLA:
Madonna, Rosalinda, et al. "Stem Cell Aging and Age-Related Cardiovascular Disease: Perspectives of Treatment by Ex-vivo Stem Cell Rejuvenation." Current Drug Targets 16.8 (2015): 780-5.
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