Primary Manifestation of Inflammatory Bowel Disease Following Subcutaneous Autovaccination

Raithel M, Weidenhiller M, Hahn M, Hagel A, Bechthold C, Neurath M, Rieker RJ, Stein J (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Journal of Crohns & Colitis Elsevier

Book Volume: 9

Pages Range: 802-5

Journal Issue: 9

DOI: 10.1093/ecco-jcc/jjv103

Abstract

Onset of inflammatory bowel disease [IBD] is nowadays seen as an interplay or a combination of genetic susceptibility, disturbed intestinal immunity, and environmental factors including gut microbiome. However, the initiation of inflammation and progression to IBD pathogenesis in a given individual is poorly understood. In this case report we describe the clinical course of a 17-year-old female patient developing symptoms suggestive of IBD after 'autovaccine therapy', in which sterilised samples of the patient's own stool were injected subcutaneously for improvement of her general immunity. The patient presented with a severe onset of disease, which was first suspected to be ulcerative colitis on outpatient examination and was later corrected to IBD with Crohn's-like features due to high systemic inflammation, mixed lymphocytic-granulocytic infiltrates in gastric biopsies, and further characteristics suggestive of Crohn's disease. A prolonged and complicated course was seen with intermittent steroid dependency in the long term. Numerous publications postulate that [auto-]immune reactions against resident bacterial stool flora may play a role in IBD. It is possible that in this patient tolerance to endogenous bacteria was disrupted by systemic pro-inflammatory mechanisms induced by autovaccination.

Authors with CRIS profile

Alexander Hagel Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Markus Neurath Lehrstuhl für Innere Medizin I

Involved external institutions

Kantonsspital Baselland CH Switzerland (CH)

How to cite

APA:

Raithel, M., Weidenhiller, M., Hahn, M., Hagel, A., Bechthold, C., Neurath, M.,... Stein, J. (2015). Primary Manifestation of Inflammatory Bowel Disease Following Subcutaneous Autovaccination. Journal of Crohns & Colitis, 9(9), 802-5. https://doi.org/10.1093/ecco-jcc/jjv103

MLA:

Raithel, Martin, et al. "Primary Manifestation of Inflammatory Bowel Disease Following Subcutaneous Autovaccination." Journal of Crohns & Colitis 9.9 (2015): 802-5.

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