Tissue sodium storage: evidence for kidney-like extrarenal countercurrent systems?
Hofmeister LH, Perisic S, Titze J (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 467
Pages Range: 551-8
Journal Issue: 3
DOI: 10.1007/s00424-014-1685-x
Abstract
Recent evidence from chemical analysis of tissue electrolyte and water composition has shown that body Na(+) content in experimental animals is not constant, does not always readily equilibrate with water, and cannot be exclusively controlled by the renal blood purification process. Instead, large amounts of Na(+) are stored in the skin and in skeletal muscle. Quantitative non-invasive detection of Na(+) reservoirs with sodium magnetic resonance imaging ((23)NaMRI) suggests that this mysterious Na(+) storage is not only an animal research curiosity but also exists in humans. In clinical studies, tissue Na(+) storage is closely associated with essential hypertension. In animal experiments, modulation of reservoir tissue Na(+) content leads to predictable blood pressure changes. The available evidence thus suggests that the patho(?)-physiological process of Na(+) storage might be of relevance for human health and disease.
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APA:
Hofmeister, L.H., Perisic, S., & Titze, J. (2015). Tissue sodium storage: evidence for kidney-like extrarenal countercurrent systems? Pflügers Archiv: European Journal of Physiology, 467(3), 551-8. https://doi.org/10.1007/s00424-014-1685-x
MLA:
Hofmeister, Lucas H., Stojan Perisic, and Jens Titze. "Tissue sodium storage: evidence for kidney-like extrarenal countercurrent systems?" Pflügers Archiv: European Journal of Physiology 467.3 (2015): 551-8.
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