Reactivity to sorbitan sesquioleate affects reactivity to fragrance mix I
Geier J, Schnuch A, Lessmann H, Uter W (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 73
Pages Range: 296-304
Journal Issue: 5
DOI: 10.1111/cod.12468
Abstract
Fragrance mix I (FM I) and its single constituents contain 5% and 1% sorbitan sesquioleate (SSO), respectively. SSO is a rare sensitizer and a potential irritant.To determine whether the outcome of the FM I breakdown test is affected by positive patch test reactivity to SSO.A retrospective analysis of data from the Information Network of Departments of Dermatology, 1998-2013, was performed.The full FM I breakdown test including SSO was tested in 2952 patients. Of these, 154 (5.2%) had a positive patch test reaction to SSO 20% pet. and 2709 (91.8%) had a negative patch test reaction. Positive reactions to one or more of the single fragrances contained in the mix were significantly more common (82.5% versus 57.3%) in SSO-positive patients, who also had more multiple reactions than FM I-positive patients with negative SSO reactions (61.5% versus 21.3% patients with reactions to two or more fragrances).Our results indicate that reactivity to SSO markedly affects the outcome of patch testing with FM I and its single constituents. SSO must be an obligatory part of the full FM I breakdown test, and should ideally be included in the baseline series.
Authors with CRIS profile
Involved external institutions
Germany (DE)How to cite
APA:
Geier, J., Schnuch, A., Lessmann, H., & Uter, W. (2015). Reactivity to sorbitan sesquioleate affects reactivity to fragrance mix I. Contact Dermatitis, 73(5), 296-304. https://doi.org/10.1111/cod.12468
MLA:
Geier, Johannes, et al. "Reactivity to sorbitan sesquioleate affects reactivity to fragrance mix I." Contact Dermatitis 73.5 (2015): 296-304.
BibTeX: Download