Basophil-derived amphiregulin is essential for UVB irradiation-induced immune suppression

Meulenbroeks C, Van Weelden H, Schwartz C, Vöhringer D, Redegeld FAM, Rutten VPMG, Willemse T, Sijts AJAM, Zaiss DMW (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Journal of Investigative Dermatology Nature Publishing Group: Open Access Hybrid Model Option A

Book Volume: 135

Pages Range: 222-8

Journal Issue: 1

DOI: 10.1038/jid.2014.329

Abstract

UVB irradiation (290-320 nm) is used to treat skin diseases like psoriasis and atopic dermatitis, and is known to suppress contact hypersensitivity (CHS) reactions in mouse models. Regulatory T cells (Treg cells) have been shown to be responsible for this UVB-induced suppression of CHS. The epidermal growth factor (EGF)-like growth factor amphiregulin (AREG) engages EGFR on Treg cells and, in different disease models, it was shown that mast cell-derived AREG is essential for optimal Treg cell function in vivo. Here we determined whether AREG has a role in UVB-induced, Treg cell-mediated suppression of CHS reactions in the skin. Our data show that AREG is essential for UVB-induced CHS suppression. In contrast to the general assumption, however, mast cells were dispensable for UVB-induced immune suppression, whereas basophil-derived AREG was essential. These data reveal, to our knowledge, a previously unreported function for basophils in the homeostasis of immune responses in the skin. Basophils thus fulfill a dual function: they contribute to the initiation of effective type 2 immune responses and, by enhancing the suppressive capacity of local Treg cell populations, also to local immune regulation in the skin.

Authors with CRIS profile

Christian Schwartz Department of Infection Biology David Vöhringer Professur für Infektionsabwehr und Toleranz

Involved external institutions

Universiteit Utrecht (UU) / Utrecht University NL Netherlands (NL) University Medical Centre Utrecht (UMC Utrecht) NL Netherlands (NL)

How to cite

APA:

Meulenbroeks, C., Van Weelden, H., Schwartz, C., Vöhringer, D., Redegeld, F.A.M., Rutten, V.P.M.G.,... Zaiss, D.M.W. (2015). Basophil-derived amphiregulin is essential for UVB irradiation-induced immune suppression. Journal of Investigative Dermatology, 135(1), 222-8. https://doi.org/10.1038/jid.2014.329

MLA:

Meulenbroeks, Chantal, et al. "Basophil-derived amphiregulin is essential for UVB irradiation-induced immune suppression." Journal of Investigative Dermatology 135.1 (2015): 222-8.

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