With a little help from my old T cell: Memory follicular T helper cells driving autoimmunity?
Winkler T, Waisman A (2014)
Publication Status: Published
Publication Type: Journal article, Note
Publication year: 2014
Journal
Publisher: Wiley-VCH Verlag
Book Volume: 44
Pages Range: 2869-2871
Journal Issue: 10
Abstract
It has long been known that the B cell repertoire includes cells that are capable of producing autoantibodies and that these cells can be found in humans and also in wild type strains of laboratory mice; however, normally, these B cells do not give rise to plasma cells, and thus do not fulfil their autoimmune potential. In this issue of the European Journal of Immunology, Nusser et al. [Eur. J. Immunol. 2014. 44: 2893-2902] dissect the mechanism by which these B cells are activated and autoantibodies are produced. The authors demonstrate that T cells, most likely antigen-specific, which accumulate with age or as a result of homeostatic proliferation, provide essential help to these autoreactive B cells. Hence, this study reveals a previously under appreciated mechanism, by which T cells, possibly generated with age after exposure to a variety of antigens, break immunological tolerance and lead to the generation of autoantibodies that could contribute to the development of autoimmune diseases.
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Germany (DE)How to cite
APA:
Winkler, T., & Waisman, A. (2014). With a little help from my old T cell: Memory follicular T helper cells driving autoimmunity? European Journal of Immunology, 44(10), 2869-2871. https://doi.org/10.1002/eji.201445101
MLA:
Winkler, Thomas, and Ari Waisman. "With a little help from my old T cell: Memory follicular T helper cells driving autoimmunity?" European Journal of Immunology 44.10 (2014): 2869-2871.
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