Censoring of autoreactive B cell development by the pre-B cell receptor
Keenan RA, De Riva A, Corleis B, Hepburn L, Licence S, Winkler T, Martensson IL (2008)
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2008
Journal
Book Volume: 321
Pages Range: 696-699
Journal Issue: 5889
Abstract
Antibody diversity occurs randomly as B cells recombine their immunoglobulin (Ig) heavy- and light-chain genes during development. This process inevitably generates reactivity against self structures, and several mechanisms prevent the development of autoreactive B cells. We report here a role for the pre-B cell receptor, composed of Ig heavy and surrogate light chains, in the negative selection of cells expressing Ig heavy chains with the potential to generate autoantibodies. Surrogate light-chain-deficient (SLC ) mice harbored elevated levels of antinuclear antibodies (ANAs) in their serum and showed evidence of escape of pre-B cells expressing prototypic autoantibody heavy chains from negative selection, leading to mature autoantibody secreting CD21CD23 B cells in the periphery. Thus, the pre-B cell receptor appears to censor the development of certain autoantibody-secreting cells and may represent an important factor in multifactorial autoimmune diseases.
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United Kingdom (GB)How to cite
APA:
Keenan, R.A., De Riva, A., Corleis, B., Hepburn, L., Licence, S., Winkler, T., & Martensson, I.-L. (2008). Censoring of autoreactive B cell development by the pre-B cell receptor. Science, 321(5889), 696-699. https://doi.org/10.1126/science.1157533
MLA:
Keenan, Rebecca A., et al. "Censoring of autoreactive B cell development by the pre-B cell receptor." Science 321.5889 (2008): 696-699.
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