Unterseher F, Hefele J, Giehl K, De Robertis E, Wedlich D, Schambony A (2004)
Publication Language: English
Publication Type: Journal article, Original article
Subtype: other
Publication year: 2004
Publisher: Nature Publishing Group
Book Volume: 23
Pages Range: 3259-3269
Journal Issue: 16
Convergent extension movements occur ubiquitously in animal development. This special type of cell movement is controlled by the Wnt/planar cell polarity (PCP) pathway. Here we show that Xenopus paraxial protocadherin (XPAPC) functionally interacts with the Wnt/PCP pathway in the control of convergence and extension (CE) movements in Xenopus laevis. XPAPC functions as a signalling molecule that coordinates cell polarity of the involuting mesoderm in mediolateral orientation and thus selectively promotes convergence in CE movements. XPAPC signals through the small GTPases Rho A and Rac 1 and c-jun N-terminal kinase (JNK). Loss of XPAPC function blocks Rho A-mediated JNK activation. Despite common downstream components, XPAPC and Wnt/PCP signalling are not redundant, and the activity of both, XPAPC and PCP signalling, is required to coordinate CE movements.
APA:
Unterseher, F., Hefele, J., Giehl, K., De Robertis, E., Wedlich, D., & Schambony, A. (2004). Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK. EMBO Journal, 23(16), 3259-3269. https://doi.org/10.1038/sj.emboj.7600332
MLA:
Unterseher, Frank, et al. "Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK." EMBO Journal 23.16 (2004): 3259-3269.
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