Detsch R (2010)
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2010
Publisher: Elsevier
Book Volume: 6
Pages Range: 3223-3233
Journal Issue: 8
DOI: 10.1016/j.actbio.2010.03.003
Nanocrystalline calcium phosphates containing carbonate have a high similarity to bone mineral. The reactions of bone cells (primary osteoblasts and osteoclast-like cells) on these materials as well as on sintered β-tricalcium phosphate and hydroxyapatite (HA) confirmed a good biocompatibility of the nanocrystalline samples. However, osteoclastic differentiation was constrained on the carbonate-rich samples, leading to a small number of osteoclast-like cells on the materials and few resorption pits. The grain size of the calcium phosphate ceramics (nano vs. micro) was less important than expected from to physico-chemical considerations. When comparing the nanocrystalline samples, the highest resorption rate was found for nano-HA with a low carbonate content, which strongly stimulated the differentiation of osteoclast-like cells on its surface. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
APA:
Detsch, R. (2010). The resorption of nanocrystalline calcium phosphates by osteoclast-like cells. Acta Biomaterialia, 6(8), 3223-3233. https://doi.org/10.1016/j.actbio.2010.03.003
MLA:
Detsch, Rainer. "The resorption of nanocrystalline calcium phosphates by osteoclast-like cells." Acta Biomaterialia 6.8 (2010): 3223-3233.
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