Detsch R (2010)
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2010
Publisher: Wiley-Blackwell
Book Volume: 92
Pages Range: 493-503
Journal Issue: 2
DOI: 10.1002/jbm.a.32386
Hydroxyapatite (HA) ceramic is a widely used synthetic bone substitute material for the regeneration of bone defects. We manufactured HA scaffolds with adjustable pore sizes and pore geometry by dispense-plotting. In addition, we attached peptides covalently onto the HA surface and are able to simultaneously quantify the amount of covalently attached and adsorbed peptide down to the picomolar range with a novel fluorescence-based detection method. In cell culture assays with stromal bone marrow cells, we observed a positive effect of biofunctionalization on cell differentiation after 21 days of culture when comparing the scaffold functionalized with the RGD motif containing adhesion peptide to an unmodified scaffold. © 2009 Wiley Periodicals, Inc.
APA:
Detsch, R. (2010). Biofunctionalization of dispense-plotted hydroxyapatite scaffolds with peptides: Quantification and cellular response. Journal of Biomedical Materials Research Part A, 92(2), 493-503. https://doi.org/10.1002/jbm.a.32386
MLA:
Detsch, Rainer. "Biofunctionalization of dispense-plotted hydroxyapatite scaffolds with peptides: Quantification and cellular response." Journal of Biomedical Materials Research Part A 92.2 (2010): 493-503.
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