The spatial properties of L- and M-cone inputs to electroretinograms that reflect different types of post-receptoral processing

Jacob MM, Pangeni G, Gomes BD, Souza GS, Da Silva Filho M, Silveira LCL, Maguire J, Parry NRA, Mckeefry DJ, Kremers J (2015)

Publication Type: Journal article

Publication year: 2015

Journal

PLoS ONE Public Library of Science

Book Volume: 10

Pages Range: e0121218

Journal Issue: 3

DOI: 10.1371/journal.pone.0121218

Abstract

We studied the spatial arrangement of L- and M-cone driven electroretinograms (ERGs) reflecting the activity of magno- and parvocellular pathways. L- and M-cone isolating sine wave stimuli were created with a four primary LED stimulator using triple silent substitution paradigms. Temporal frequencies were 8 and 12 Hz, to reflect cone opponent activity, and 30, 36 and 48 Hz to reflect luminance activity. The responses were measured for full-field stimuli and for different circular and annular stimuli. The ERG data confirm the presence of two different mechanisms at intermediate and high temporal frequencies. The responses measured at high temporal frequencies strongly depended upon spatial stimulus configuration. In the full-field conditions, the L-cone driven responses were substantially larger than the full-field M-cone driven responses and also than the L-cone driven responses with smaller stimuli. The M-cone driven responses at full-field and with 70° diameter stimuli displayed similar amplitudes. The L- and M-cone driven responses measured at 8 and 12 Hz were of similar amplitude and approximately in counter-phase. The amplitudes were constant for most stimulus configurations. The results indicate that, when the ERG reflects luminance activity, it is positively correlated with stimulus size. Beyond 35° retinal eccentricity, the retina mainly contains L-cones. Small stimuli are sufficient to obtain maximal ERGs at low temporal frequencies where the ERGs are also sensitive to cone-opponent processing.

Authors with CRIS profile

Jan Kremers Professur für Experimentelle Augenheilkunde

Involved external institutions

Central Manchester University Hospitals GB United Kingdom (GB) University of Manchester GB United Kingdom (GB) University of Bradford GB United Kingdom (GB) Universidade Federal do Pará (UFPA) BR Brazil (BR)

How to cite

APA:

Jacob, M.M., Pangeni, G., Gomes, B.D., Souza, G.S., Da Silva Filho, M., Silveira, L.C.L.,... Kremers, J. (2015). The spatial properties of L- and M-cone inputs to electroretinograms that reflect different types of post-receptoral processing. PLoS ONE, 10(3), e0121218. https://doi.org/10.1371/journal.pone.0121218

MLA:

Jacob, Mellina M., et al. "The spatial properties of L- and M-cone inputs to electroretinograms that reflect different types of post-receptoral processing." PLoS ONE 10.3 (2015): e0121218.

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