Nimmerjahn F, Lux A, Albert H, Woigk M, Lehmann C, Dudziak D, Smith P, Ravetch JV (2010)
Publication Status: Published
Publication Type: Journal article
Publication year: 2010
Book Volume: 107
Pages Range: 19396-401
Journal Issue: 45
Cellular Fcγ receptors are essential for IgG-dependent effector functions in vivo. There is convincing evidence that selective activating Fcγ receptors are responsible for the activity of individual IgG subclasses. Thus, IgG1 activity is absent in FcγRIII-deficient mice, and several studies suggest that the activity of the most potent IgG subclasses, IgG2a and IgG2b, might be dependent on either individual or a combination of activating FcγRs. To study the role of individual activating FcγRs for IgG subclass activity, we generated an FcγRIV-deficient mouse and showed that a variety of IgG2a- and IgG2b-dependent effector functions are impaired in the absence of this activating Fc receptor in models of autoimmunity and antibody-dependent cellular cytotoxicity.
APA:
Nimmerjahn, F., Lux, A., Albert, H., Woigk, M., Lehmann, C., Dudziak, D.,... Ravetch, J.V. (2010). FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo. Proceedings of the National Academy of Sciences of the United States of America, 107(45), 19396-401. https://doi.org/10.1073/pnas.1014515107
MLA:
Nimmerjahn, Falk, et al. "FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo." Proceedings of the National Academy of Sciences of the United States of America 107.45 (2010): 19396-401.
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