Aschermann S, Lehmann C, Mihai S, Schett G, Dudziak D, Nimmerjahn F (2013)
Publication Status: Published
Publication Type: Journal article
Publication year: 2013
Book Volume: 110
Pages Range: 19042-7
Journal Issue: 47
Impaired regulatory T-cell function results in a severe chronic autoimmune disease affecting multiple organs in Scurfy mice and humans with the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Previous studies have shown that T helper cells but not cytotoxic T cells are critical for the disease pathology. Whether this T-cell subset is responsible directly for tissue inflammation or rather indirectly via the interaction with B cells or myeloid cells is largely unknown. To study this and to identify potential therapeutic targets for this lethal disease we investigated the contribution of B cells to this complex autoimmune phenotype. We show that B cells and the production of autoantibodies plays a major role for skin, liver, lung, and kidney inflammation and therapeutic depletion of B cells resulted in reduced tissue pathology and in prolonged survival. In contrast, the absence of B cells did not impact systemic T-cell activation and hyperreactivity, indicating that autoantibody production by B cells may be a major factor for the autoimmune pathology in mice deficient for regulatory T cells.
APA:
Aschermann, S., Lehmann, C., Mihai, S., Schett, G., Dudziak, D., & Nimmerjahn, F. (2013). B cells are critical for autoimmune pathology in Scurfy mice. Proceedings of the National Academy of Sciences of the United States of America, 110(47), 19042-7. https://doi.org/10.1073/pnas.1313547110
MLA:
Aschermann, Susanne, et al. "B cells are critical for autoimmune pathology in Scurfy mice." Proceedings of the National Academy of Sciences of the United States of America 110.47 (2013): 19042-7.
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