Zaffran S, Xu X, Lo PC, Lee HH, Frasch M (2002)
Publication Status: Published
Publication Type: Book chapter / Article in edited volumes
Publication year: 2002
Publisher: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Edited Volumes: Cold Spring Harb Symp Quant Biol
Book Volume: 67
Pages Range: 1-12
The dorsal vessel of Drosophila displays developmental, functional, and morphological similarities to the primitive linear heart tube of early vertebrate embryos. Because these similarities extend to the genetic and molecular level, Drosophila has become a fruitful model to study control mechanisms of early heart development. Herein we summarize recently obtained insights into control mechanisms during early induction and diversification of cardiac progenitors in Drosophila. We also show that induction of tinman, a key cardiogenic gene, in the dorsal mesoderm by Dpp (Drosophila BMP) involves protein/protein interactions between Tinman and the Smad proteins Mad and Medea, in addition to their DNA-binding activities to specific tinman enhancer sequences. Furthermore, we present evidence that binding of a high-mobility-group protein, HMG-D, to the Dpp-responsive enhancer of tinman as well as to the Tinman protein may be involved in the formation of a fully active enhancer complex.
APA:
Zaffran, S., Xu, X., Lo, P.C., Lee, H.-H., & Frasch, M. (2002). Cardiogenesis in the Drosophila model: Control mechanisms during early induction and diversification of cardiac progenitors. In Cold Spring Harb Symp Quant Biol. (pp. 1-12). COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT.
MLA:
Zaffran, Stéphane, et al. "Cardiogenesis in the Drosophila model: Control mechanisms during early induction and diversification of cardiac progenitors." Cold Spring Harb Symp Quant Biol. COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 2002. 1-12.
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