Plasma concentrations of the amyloid-? peptides in young volunteers: the influence of the APOE genotype
Zimmermann R, Huber E, Schamber C, Lelental N, Mroczko B, Brandner S, Maler JM, Oberstein T, Szmitkowski M, Rauh M, Kornhuber J, Lewczuk P (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 40
Pages Range: 1055-60
Journal Issue: 4
DOI: 10.3233/JAD-132687
Abstract
Changes in the concentrations of amyloid-? (A?) in the body fluids are the earliest alterations observed in Alzheimer's disease (AD), however, there is a lack of data about how early these alterations occur, before the onset of the clinical symptoms. APOE genotype is the most recognized genetic risk/protective factor of AD, meaning that a group of non-demented persons carrying ?4 allele is enriched in the subjects who will develop AD, compared to the group of non-carriers. Therefore, we studied the plasma concentrations of A? peptides (A?1-42, A?1-40, A?x-42, and A?x-40), and the APOE genotype in 173 young volunteers (average age, 28 ± 7.6 years) without memory deficits, in order to see whether the non-demented group of subjects at risk already characterize with A? changes three-to-four decades before the age at which dementia usually occurs. We did not find statistically significant differences among the groups of ?4 carriers, ?3 homozygotes, and ?2 carriers. We conclude that the APOE genotype does not influence the metabolism of the A? peptides in young persons without memory deficits.
Authors with CRIS profile
Christine Schamber
Medizinische Fakultät
Natalia Ermann
Medizinische Fakultät
Sebastian Brandner
Department of Neurosurgery
Timo Oberstein
Medizinische Fakultät
Manfred Rauh
Department of Paediatrics and Adolescent Medicine
Johannes Kornhuber
Lehrstuhl für Psychiatrie und Psychotherapie
Piotr Lewczuk
Department of Psychiatry and Psychotherapy
Involved external institutions
Poland (PL)How to cite
APA:
Zimmermann, R., Huber, E., Schamber, C., Lelental, N., Mroczko, B., Brandner, S.,... Lewczuk, P. (2014). Plasma concentrations of the amyloid-? peptides in young volunteers: the influence of the APOE genotype. Journal of Alzheimer's Disease, 40(4), 1055-60. https://doi.org/10.3233/JAD-132687
MLA:
Zimmermann, Rüdiger, et al. "Plasma concentrations of the amyloid-? peptides in young volunteers: the influence of the APOE genotype." Journal of Alzheimer's Disease 40.4 (2014): 1055-60.
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