Olfactory training is helpful in postinfectious olfactory loss: A randomized, controlled, multicenter study

Damm M, Pikart LK, Reimann H, Burkert S, Goektas O, Haxel B, Frey S, Charalampakis I, Beule A, Renner B, Hummel T, Huettenbrink KB (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Laryngoscope Wiley-Blackwell

Book Volume: 124

Pages Range: 826-31

Journal Issue: 4

DOI: 10.1002/lary.24340

Abstract

The aim of this study was to evaluate the effects of olfactory training (OT) on olfactory function in patients with persistent postinfectious olfactory dysfunction (PIOD).Randomized, single-blind, controlled, multicenter crossover study.Twelve tertiary university medical centers participated. Investigations were performed at three visits (baseline, after 18 weeks, and after 36 weeks), including only subjects with PIOD of <24-months duration. At each visit, participants received detailed assessment of olfactory function. Seventy subjects trained with high concentrations of four odors for 18 weeks; the other half (n = 74) trained with low concentrations of odors. For the following 18 weeks this regimen was switched.After 18 weeks, olfactory function improved in the high-training group in 18 of 70 participants (26%), whereas only 11/74 improved in the low-training group (15%). In subjects with a duration of olfactory dysfunction of <12 months, olfactory function improved in 15/24 participants (63%) of the high-training group and in 6/31 participants (19%) of the low-training group (P = .03).OT improves PIOD, and the use of odors at higher concentrations is beneficial to improvement. OT is a safe procedure and appears to be particularly useful in patients who start OT within 12 months after the onset of the disorder. OT is the first successful therapy regime in patients with PIOD.1b. Laryngoscope, 124:826-831, 2014.

Authors with CRIS profile

Bertold Renner Lehrstuhl für Pharmakologie und Toxikologie

Involved external institutions

Universitätsmedizin Greifswald / Universitätsklinikum Greifswald DE Germany (DE) Universitätsklinikum Köln DE Germany (DE) Universitätsklinikum Magdeburg A.ö.R. DE Germany (DE) Universitätsklinikum Mannheim DE Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) Martin-Luther-Universität Halle-Wittenberg (MLU) DE Germany (DE) Universitätsklinikum Jena DE Germany (DE) Technische Universität Dresden DE Germany (DE)

How to cite

APA:

Damm, M., Pikart, L.K., Reimann, H., Burkert, S., Goektas, O., Haxel, B.,... Huettenbrink, K.-B. (2014). Olfactory training is helpful in postinfectious olfactory loss: A randomized, controlled, multicenter study. Laryngoscope, 124(4), 826-31. https://doi.org/10.1002/lary.24340

MLA:

Damm, Michael, et al. "Olfactory training is helpful in postinfectious olfactory loss: A randomized, controlled, multicenter study." Laryngoscope 124.4 (2014): 826-31.

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