A cyclometalated diplatinum complex containing 1,1 '-bis(diphenylphosphino)ferrocene as spacer ligand: Antitumor study
Samouei H, Rashidi M, Heinemann FW (2011)
Publication Status: Published
Publication Type: Journal article
Publication year: 2011
Journal
Publisher: ELSEVIER SCIENCE SA
Book Volume: 696
Pages Range: 3764-3771
Journal Issue: 23
DOI: 10.1016/j.jorganchem.2011.08.038
Abstract
Cyclometalated platinum(II) complex [Pt(C boolean AND N)Cl(dmso)], 1, in which C boolean AND N = N(1),C(2')-chelated deprotonated 2-phenylpyridine and dmso = dimethylsulfoxide, was reacted with 1 equiv of 1,1'-bis(diphenylphosphino) ferrocene, dppf, to give the cyclometalated diplatinum(II) complex [Pt-2(C boolean AND N)(2)Cl-2(mu-dppf)], 2, along with 0.5 equiv of unreacted dppf. However, the related reaction with 0.5 equiv of dppf produced complex 2 in pure form. Complex 2 in solution was fully characterized by using multinuclear NMR spectroscopy (H-1, C-13, P-31, and Pt-195) and a number of 2D NMR experiments. The structure of complex 2 in solid state was determined by X-ray crystallography showing that the bridging dppf ligand is arranged close to "antiperiplanar staggered" conformation. Cytotoxicity of the complex 2 was studied in three human cancer cell lines derived from ovarian carcinoma(CH1), lung carcinoma(A549), and colon carcinoma (SW480) by means of the MTT assay (MTT = 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide). (C) 2011 Elsevier B.V. All rights reserved.
Authors with CRIS profile
Involved external institutions
Iran, Islamic Republic of (IR)How to cite
APA:
Samouei, H., Rashidi, M., & Heinemann, F.W. (2011). A cyclometalated diplatinum complex containing 1,1 '-bis(diphenylphosphino)ferrocene as spacer ligand: Antitumor study. Journal of Organometallic Chemistry, 696(23), 3764-3771. https://doi.org/10.1016/j.jorganchem.2011.08.038
MLA:
Samouei, Hamidreza, Mehdi Rashidi, and Frank Wilhelm Heinemann. "A cyclometalated diplatinum complex containing 1,1 '-bis(diphenylphosphino)ferrocene as spacer ligand: Antitumor study." Journal of Organometallic Chemistry 696.23 (2011): 3764-3771.
BibTeX: Download