Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells
Zeindl-Eberhart E, Brandl L, Liebmann S, Ormanns S, Scheel SK, Brabletz T, Kirchner T, Jung A (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Book Volume: 9
Pages Range: e87386
Journal Issue: 1
DOI: 10.1371/journal.pone.0087386
Abstract
Tumor cells are stressed by unfavorable environmental conditions like hypoxia or starvation. Driven by the resulting cellular stress tumor cells undergo epithelial-mesenchymal transition. Additionally, cellular stress is accompanied by endoplasmic reticulum-stress which induces an unfolded protein response. It is unknown if epithelial-mesenchymal transition and endoplasmic reticulum-stress are occurring as independent parallel events or if an interrelationship exists between both of them. Here, we show that in colorectal cancer cells endoplasmic reticulum-stress depends on the induction of ZEB-1, which is a main factor of epithelial-mesenchymal transition. In the absence of ZEB-1 colorectal cancer cells cannot mount endoplasmic reticulum-stress as a reaction on cellular stress situations like hypoxia or starvation. Thus, our data suggest that there is a hierarchy in the development of cellular stress which starts with the presence of environmental stress that induces epithelial-mesenchymal transition which allows finally endoplasmic reticulum-stress. This finding highlights the central role of epithelial-mesenchymal transition during the process of tumorigenesis as epithelial-mesenchymal transition is also associated with chemoresistance and cancer stemness. Consequently, endoplasmic reticulum-stress might be a well suited target for chemotherapy of colorectal cancers.
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Germany (DE)How to cite
APA:
Zeindl-Eberhart, E., Brandl, L., Liebmann, S., Ormanns, S., Scheel, S.K., Brabletz, T.,... Jung, A. (2014). Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells. PLoS ONE, 9(1), e87386. https://doi.org/10.1371/journal.pone.0087386
MLA:
Zeindl-Eberhart, Evelyn, et al. "Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells." PLoS ONE 9.1 (2014): e87386.
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