Kuenzel J, Geisler K, Maltaris T, Mueller A, Hoffmann I, Schneider H, Beckmann M, Dittrich R, Oppelt P (2014)
Publication Type: Journal article
Publication year: 2014
Book Volume: 28
Pages Range: 467-75
Journal Issue: 4
Uterine quiescence at the time of embryo transfer is a prerequisite for successful in vitro fertilization (IVF). This study assessed whether prostaglandin-induced contractions in the perfused swine uterus can be reduced by progesterone.Fifty-eight non-pregnant swine uteri were perfused using an established extracorporeal perfusion model. Intrauterine pressure changes during perfusion with prostaglandin (PG) administration (PGE1, PGE2, PGF2?) and progesterone (1 pg/ml, 10 pg/ml, 25 pg/ml, 50 pg/ml) were assessed using an intrauterine double-chip microcatheter.The contraction-stimulating effect of PGs was clearly reduced by progesterone. Only PGE1 still triggered relevant contractions during continuous perfusion with progesterone solution, up to a concentration of 10 pg/ml. With PGE2 and PGF2?, a clear reduction of uterine contractility was observed even at at a progesterone concentration of 1 pg/ml.The extracorporal perfusion model of swine uteri shows that PG-induced contractions can be reduced in a dose-dependent manner by progesterone.
APA:
Kuenzel, J., Geisler, K., Maltaris, T., Mueller, A., Hoffmann, I., Schneider, H.,... Oppelt, P. (2014). Effects of interactions between progesterone and prostaglandin on uterine contractility in a perfused swine uterus model. In Vivo, 28(4), 467-75.
MLA:
Kuenzel, Julian, et al. "Effects of interactions between progesterone and prostaglandin on uterine contractility in a perfused swine uterus model." In Vivo 28.4 (2014): 467-75.
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