Kralj A, Kurt E, Tschammer N, Heinrich M (2014)
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2014
Book Volume: 9
Pages Range: 151-168
Journal Issue: 1
To prepare and biologically evaluate 38 new potential US28 allosteric modulators, we employed a straightforward synthetic route involving radical arylation. The study was based on a former lead structure but with the dihydroisoquinolinone moiety replaced by substituted biphenyls. The investigation of structure-activity relationships among the new biphenyl-derived ligands led to a preliminary pharmacophore model and the discovery of four promising candidates with full inverse agonist properties. Hit HCMV GPCRs ASAP! Employing a straightforward synthetic access involving radical arylation, 38 new potential US28 allosteric modulators were prepared and biologically evaluated. The investigation of structure-activity relationships among the new biphenyl-derived ligands led to a consistent model and the discovery of four promising candidates with full inverse agonist properties. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
APA:
Kralj, A., Kurt, E., Tschammer, N., & Heinrich, M. (2014). Synthesis and biological evaluation of biphenyl amides that modulate the US28 receptor. ChemMedChem, 9(1), 151-168. https://doi.org/10.1002/cmdc.201300369
MLA:
Kralj, Ana, et al. "Synthesis and biological evaluation of biphenyl amides that modulate the US28 receptor." ChemMedChem 9.1 (2014): 151-168.
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