Swernath S, Kaspereit M, Kienle A (2013)
Publication Language: English
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2013
Publisher: Wiley-VCH Verlag
Book Volume: 36
Pages Range: 1417-1429
Journal Issue: 8
The combination of continuous chromatographic processes and subsequent crystallization with a recycle of the mother liquor can improve significantly the efficiency of separation processes for the production of enantiomers if compared to the stand-alone chromatographic process. For the first time, dynamic operability and plantwide control of such a process combination is investigated. In the first step, the effect of disturbances on the open loop dynamics is evaluated. In a second step, a simple plantwide control strategy is proposed in order to ensure a robust process operation. It is demonstrated that the direct control of the simulated moving bed (SMB) unit is not required to stabilize the process combination while maintaining the desired product specifications. Instead, this can be achieved easily by controlling the amount of solvent removed or added to the system. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
APA:
Swernath, S., Kaspereit, M., & Kienle, A. (2013). Dynamics and control of coupled continuous chromatography and crystallization processes for the production of pure enantiomers. Chemical Engineering & Technology, 36(8), 1417-1429. https://doi.org/10.1002/ceat.201200279
MLA:
Swernath, Subramanian, Malte Kaspereit, and Achim Kienle. "Dynamics and control of coupled continuous chromatography and crystallization processes for the production of pure enantiomers." Chemical Engineering & Technology 36.8 (2013): 1417-1429.
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